C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4709 (2006.01) A61K 33/24 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2706420
The present invention relates to a transition metal complex represented by Formula (I) or salts thereof, or to a ligand represented by Formula (H) or salts thereof, wherein X represents a transition metal, preferably Pt, and methods for their use and preparation. In particular, the invention relates to compounds which may possess useful therapeutic activity in treating amyloid diseases, and in particular, Alzheimer's disease. The invention also relates to the use of these compounds in methods of therapy, and diagnosis, and the manufacture of medicaments as well as compositions containing these compounds.
Cette invention concerne un complexe à base de métal de transition représenté par la formule (I) ou ses sels, ou un ligand représenté par la formule (H) ou ses sels, où X représente un métal de transition, de préférence Pt, et des procédés permettant de les utiliser et de les préparer. L'invention concerne en particulier des composés susceptibles d'avoir une activité thérapeutique utile dans le traitement des maladies amyloïdes et, en particulier, la maladie d'Alzheimer. L'invention concerne également l'utilisation de ces composés dans des procédés thérapeutiques et diagnostiques, et la fabrication de médicaments et de compositions contenant ces composés.
Barnham Kevin Jeffrey
Kenche Vijaya
Benoit & Cote Associes Inc.
Prana Biotechnology Ltd
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