C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/56 (2006.01) A61K 31/423 (2006.01) A61K 31/424 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2756989
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuro-muscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formula-tions containing the compounds and their methods of use are also provided herein.
La présente invention concerne des composés et leurs procédés de synthèse. Les composés de l'invention sont utilisables dans le cadre du traitement, de la prévention et/ou de la prise en charge de diverses affections, telles que des affections neurologiques, psychiatriques, neuromusculaires, gastro-intestinales, des affections touchant l'appareil urinaire inférieur et le cancer. Les composés de l'invention modulent l'activité du récepteur métabotropique 5 au glutamate (mGluR5) dans le système nerveux central ou périphérique. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que leurs procédés d'utilisation.
Burdi Douglas
Hardy Larry Wendell
Spear Kerry L.
Dainippon Sumitomo Pharma Co. Ltd.
Kirby Eades Gale Baker
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