C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 31/16 (2006.01) A61P 25/04 (2006.01) C07C 279/12 (2006.01)
Patent
CA 2720375
The present invention relates to a compound of formula I (I) wherein X is hydrogen, R1, RIC(O), R1C02, or a COX2 inhibitor, wherein R1 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy; wherein Y is 0R2, NHR3 N(R3)2, or a COX inhibitor; wherein R2 is hydrogen or C1-20 alkyl and each R3 is independently hydrogen or a C1-4 alkyl; wherein T is 0R4, NHR5 N(R5)2, or a COX inhibitor; wherein R4 is hydrogen or C1-20 alkyl and each R5 is independently hydrogen or a C1-4 alkyl; wherein Z is hydrogen, R6, R6C(0), R6CO2, or a C0X2 inhibitor; wherein R6 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy; with the proviso wherein when X and Z are hydrogen and T is OH, Y is not OH; for use in the prevention and/or treatment of pain wherein said compound is provided for systemic administration.
La présente invention concerne un composé de formule (I), dans laquelle X est hydrogène, R1, R1C(O), R1CO2 ou un inhibiteur de COX2, R1 est alkyle C1-20, aryle, arylalkyle, alkyloxy ou arylalkyloxy, Y est OR2, NHR3 N(R3)2 ou un inhibiteur de COX, R2 est hydrogène ou alkyle C1-20 et chaque R3 est indépendamment hydrogène ou alkyle C1-4, T est OR4, NHR5 N(R5)2 ou un inhibiteur de COX, R4 est hydrogène ou alkyle C1-20 et chaque R5 est indépendamment hydrogène ou alkyle C1-4, Z est hydrogène, R6, R6C(O), R6CO2 ou un inhibiteur de COX2, et R6 est alkyle C1-20, aryle, arylalkyle, alkyloxy ou arylalkyloxy, à condition que, lorsque X et Z sont hydrogène et T est OH, Y ne soit pas OH. Ledit composé trouve une utilisation dans la prévention et/ou le traitement de la douleur et s'administre par voie systémique.
Bardaji Rodriguez Eduard
Bernardo de Sousa Jose Manuel
Calado Patricia Ramalhete Mendes Da Silva
Castanho Miguel Augusto Rico Botas
Cerejo Marta Isabel Heitor
Bioalvo - Servicos Investigacao E. Desenvolvimento Em Biotecnologia S.a.
Smart & Biggar
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