G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/84 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2434850
Numerous diseases and disorders are caused or exacerbated by the formation of crystalline aggregates of a biomolecule that is normally in solution. Such diseases and disorders include cataracts, sickle cell anemia, atherosclerosis, kidney stones, gallstones, gout, and Alzheimer's disease. The present invention provides methods to identify compounds that can inhibit the adverse formation of crystalline aggregates, including fibrils, of a target biomolecule. These methods include the screening of large combinatorial libraries. The identified compounds are tested for their therapeutic utility in treating medical conditions caused or exacerbated by the adverse crystallization of biomolecules. Molecules that are slight modifications of the target biomolecule are found to be particularly effective in inhibiting the adverse crystallization, including fibril formation, of a target biomolecule.
De nombreuses maladies et troubles sont dus ou sont exacerbés par la formation d'agrégats cristallins d'une biomolécule se trouvant normalement en solution. Ces maladies et troubles sont la cataracte, la drépanocytose, les calculs rénaux, les calculs biliaires, la goutte et la maladie d'Alzheimer. Cette invention porte sur des procédés d'identification de composés qui peuvent inhiber la formation indésirable d'agrégats cristallins, tels que des fibrilles, d'une biomolécule cible. Ces procédés consistent à cribler de grandes bibliothèques combinatoires. Puis on teste les composés identifiés en vue de déterminer leur utilité dans le traitement d'états pathologiques dus ou exacerbés par la cristallisation indésirable de biomolécules. Les molécules qui sont de légères modifications de la biomolécule cible s'avèrent être particulièrement efficaces dans l'inhibition de la cristallisation indésirable, telle que la formation de fibrilles, d'une biomolécule cible.
Marks & Clerk
Shell John W.
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