Compounds for treating urinary incontinence

Details Compounds for treating urinary incontinence Compounds for treating urinary incontinence

C - Chemistry, Metallurgy

07

C

C07C 235/74 (2006.01) A61K 31/164 (2006.01) C07C 235/02 (2006.01)

Patent

CA 2591537

The invention relates to compounds of formula (I) or a pharmaceutically acceptable solvate or salt thereof, including a solvate of such a salt, wherein R1 is a group such that a compound of formula (I) is a prodrug of 1R,2S- methoxamine that is converted within the kidney tubules into its active form or an active metabolite thereof. The compounds find particular use in the treatment or prophylaxis of urinary incontinence.

L'invention concerne des composés de formule (I) ou un solvate ou un sel pharmaceutiquement acceptable de ces composés, y compris un solvate de ce sel. Dans cette formule, R1 est un groupe de sorte qu'un composé de formule (I) soit un promédicament de 1R,2S-méthoxamine converti dans les tubules rénaux en sa forme active ou en un métabolite actif de celle-ci. Lesdits composés trouvent notamment une utilisation dans le traitement ou la prévention de l'incontinence urinaire.

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