C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/34 (2006.01) A61K 31/16 (2006.01) A61K 31/17 (2006.01) A61K 31/175 (2006.01) A61K 31/19 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/36 (2006.01) A61K 31/44 (2006.01) A61P 3/10 (2006.01) C07C 233/25 (2006.01) C07C 235/28 (2006.01) C07C 235/56 (2006.01) C07C 237/22 (2006.01) C07C 271/16 (2006.01) C07C 271/64 (2006.01) C07C 275/50 (2006.01) C07C 281/06 (2006.01) C07C 317/22 (2006.01) C07C 335/26 (2006.01) C07D 213/56 (2006.01) C07D 213/643 (2006.01) C07D 213/75 (2006.01) C07D 295/182
Patent
CA 2468302
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
La présente invention concerne des acyle urée, thiourée, carbamate, thiocarbamate et autres nouveaux composés associés, permettant d'inhiber la réponse inflammatoire induite par la cytokine dans des cellules de culture, d'améliorer la destruction osseuse dans un modèle animal de l'arthrite, et de réduire les niveaux de glycémie dans des modèles animaux de diabètes sucrés de Type II. L'invention concerne des composés pouvant être utilisés dans plusieurs traitements, parmi lesquels le traitements des diabètes sucrés, de l'insulinorésistance, de l'inflammation, des maladies inflammatoires, des maladies immunologiques et du cancer.
Chen Liang
Dey Debendranath
Fuller Joseph
Li Ta-Kai
Neogi Partha
Gowling Lafleur Henderson Llp
Theracos Inc.
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