C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/78 (2006.01) A61Q 90/00 (2009.01) A61K 8/37 (2006.01) A61K 31/235 (2006.01) A61K 31/24 (2006.01) A61P 3/06 (2006.01) A61Q 5/00 (2006.01) A61Q 19/00 (2006.01) C07C 205/57 (2006.01)
Patent
CA 2614585
Novel benzoquinone-derived compounds and polymorphs and prodrugs thereof, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and active polymorphs, prodrugs, isomers or pharmaceutically acceptable salts, esters thereof and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, metabolic disorders, skin, hair, and cosmetic are provided.
La présente invention concerne de nouveaux composés dérivés de la benzoquinone ainsi que des polymorphes et promédicaments de ceux-ci, des isomères géométriques ou optiques de ceux-ci ainsi que des esters, éthers, carbamates, oximes pharmaceutiquement acceptables de ces composés, polymorphes, promédicaments et isomères. L~invention concerne la préparation de composés selon l~invention et de compositions pharmaceutiques contenant de tels composés et des polymorphes, promédicaments, isomères actifs ou sels et esters pharmaceutiquement acceptables de ceux-ci, ainsi que leur utilisation en vue de réduire ou d~inhiber l~activité de la famille génétique de la lipase pour le traitement, l~amélioration ou la prévention des maladies induites par famille génétique de la lipase et les pathologies incluant la surcharge pondérale, l~obésité, l~hyperlipidémie, l~hypercholestérolémie, l~hypertriglycéridémie, la pancréatite, le diabète, l~athérosclérose, d~autres maladies cardiovasculaires, les syndromes métaboliques, les troubles métaboliques, cutanés, les troubles des cheveux et les troubles esthétiques.
Gangan Vijay
Kanekar Yogesh
Upadhyay Shakti
Yadav Raman
Reliance Life Sciences Pvt Ltd
Ridout & Maybee Llp
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