A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/282 (2006.01) A61K 31/12 (2006.01) A61K 31/352 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2645600
This invention comprises an extract of Artemisia dracunculus that can be used for the treatment and prevention of diabetes, diabetic complications, metabolic syndrome and other comorbidities that share the underlying commonality of insulin resistance. The invention includes the identity of six compounds from the extract that contribute to the activity of the extract by inhibiting protein tyrosine phosphatase- 1B (PTP-1B) activity, phosphoenolpyruvate carboxykinase (PEPCK) gene expression or aldose reductase activity (ALR2). The compounds include 4, 5-Di-O- caffeoylquinic acid, davidigenin, 6-demethoxycapilIarisin, 2',4-dihydroxy-4'- methoxydihydrochalcone, 2',4'-dihydroxy-4-.rnethoxydihydrochalcone and sakuranetin.
Cette invention concerne un extrait d'Artemisia dracunculus qui peut être utilisé pour le traitement et la prévention du diabète, de complications diabétiques, d'un syndrome métabolique et d'autres comorbidités qui ont le point commun sous-jacent de la résistance à l'insuline. L'invention concerne six composés identifiés provenant de l'extrait qui contribuent à l'activité de l'extrait en inhibant l'activité de la protéine tyrosine phosphatase-1B (PTP-1B), l'expression du gène de la phosphoénolpyruvate carboxykinase (PEPCK) ou l'activité de l'aldose réductase (ALR2). Les composés comprennent l'acide 4,5-di-O-caféoylquinique, la davidigenine, la 6-déméthoxycapillarisine, la 2',4-dihydroxy-4'-méthoxydihydrochalcone, la 2',4'-dihydroxy-4-méthoxydihydrochalcone et la sakuranetine.
Cefalu William T.
Logendra Sithes
Poulev Alexander
Raskin Ilya
Ribnicky David M.
Borden Ladner Gervais Llp
Rutgers The State University Of New Jersey
LandOfFree
Compounds from an extract of artemisia and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds from an extract of artemisia and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds from an extract of artemisia and methods for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1430334