Compounds from myrothecium sp. for inhibiting the growth of...

A - Human Necessities – 61 – K

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A61K 31/365 (2006.01) A61K 36/06 (2006.01) A61P 35/00 (2006.01) C07D 493/22 (2006.01)

Patent

CA 2701626

A Myrothecium sp. mycelial extract for inhibiting tumor cells growth, especially verrucarin A and verrucarin J extracted from Myrothecium sp. mycelium. Verrucarin A and verrucarin J are used for inhibiting the growth of human hepatoma carcinoma cell Hep3B and HepG2, human lung carcinoma cell A549, and human prostatic carcinoma cell LNCaP and DU-145, and are used in the pharmaceutical composition for inhibiting the growth of human hepatoma carcinoma cell, human lung carcinoma cell, and human prostatic carcinoma cell.

La présente invention concerne un extrait mycélien de l'espèce Myrothecium destiné à l'inhibition de la croissance de cellules tumorales, spécialement la verrucarine A et la verrucarine J extraites du mycélium de l'espèce Myrothecium. La verrucarine A et la verrucarine J sont employées pour inhiber la croissance des cellules de carcinome hépatocellulaire humain Hep3B et HepG2, des cellules de carcinome pulmonaire humain A549 et des cellules de carcinome prostatique humain LNCaP et DU-145 et elles sont employées dans la composition pharmaceutique destinée à l'inhibition de la croissance des cellules de carcinome hépatocellulairehumain, des cellules de carcinome pulmonaire humain et des cellules de carcinome prostatique humain.

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