Compounds having a physiological cooling effect and...

C - Chemistry – Metallurgy – 07 – D

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260/325.1, 260/2

C07D 295/18 (2006.01) A23L 1/226 (2006.01) C07D 295/185 (2006.01) C12G 3/06 (2006.01)

Patent

CA 1041506

Abstract of the Disclosure A novel group of compounds are described having a physiological cooling effect on the skin and mucous membranes of the body but lacking the strong odour of menthol. The compounds are trialkyl-substituted cyclohex?necarboxamides of the formula Image where three of R', R", R''' and R'? are C1-C5 alkyl groups and the other is hydrogen, R', R", R''' and R'? together providing a total of form 3 - 5 carbon atoms; R1 and R2, when taken separately are each selected from hydrogen. C1-C5 alkyl, C1-C8 hydroxyalkyl and C1-C8 alkoxyalkyl, and together provide a total of no more than 1 carbon atoms, with the proviso that when R1 is hydrogen, R2 may also be alkylcarboxylalkyl of up to 6 carbon atoms; and R1 and R?, when taken together, represent an alkylene of alkylene oxyalkylene group of up to 6 carbon atoms.

194833

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