Compounds having activity as inhibitors of cytochrome p450rai

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 311/74 (2006.01) A61K 31/192 (2006.01) A61K 31/352 (2006.01) A61K 31/47 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) C07C 57/38 (2006.01) C07C 59/64 (2006.01) C07C 59/72 (2006.01) C07C 59/82 (2006.01) C07C 65/19 (2006.01) C07C 65/28 (2006.01) C07C 229/46 (2006.01) C07D 215/06 (2006.01) C07D 217/04 (2006.01) C07D 335/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2420869

Compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

L'invention concerne des composés représentés par les formules 1 à 8. Les symboles de ces formules sont tels que définis dans le corps de l'invention. Il s'agit de composés tenant lieu d'inhibiteurs de l'enzyme cytochrome P450RAI (à induction par le biais de l'acide rétinoïque), utilisés pour le traitement de troubles réagissant à des formes de traitement qui font appel aux rétinoïdes.

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