A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/47 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 38/40 (2006.01) C12N 5/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2600869
The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or post- translational modification) of a mutant-cystic fibrosis transmembrane conductance regulator protein (e.g., .DELTA.F508 CFTR) that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more aminobenzothiazole- containing compounds, aminoarylthiazole-containing compounds, quinazolinylaminopyrimidinone-containing compounds, bisaminomethylbithiazole- containing compounds, or phenylaminoquinoline-containing compounds of the invention, or an analog or derivative thereof.
L'invention concerne des compositions, des préparations pharmaceutiques et des procédés de correction de traitement cellulaire (par exemple, le pliage, le trafic et la modification post-translatoire) d'une protéine du régulateur de la conductance transmembranaire de la fibrose mutant-kystique (par exemple, ?F508 CFTR) utiles dans le traitement de la fibrose kystique (CF). Les compositions et les préparations pharmaceutiques selon l'invention peuvent comprendre un ou plusieurs composés renfermant de l'aminobenzothiazole, des composés renfermant de l'aminoarylthiazole, des composés renfermant de la quinazolinylaminopyrimidinone, des composés renfermant du bisaminométhylbithiazole ou des composés renfermant de la phénylaminoquinoline selon l'invention ou un analogue ou dérivé de ceux-ci.
Galietta Luis J. V.
Pedemonte Nicoletta
Verkman Alan
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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