C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/34 (2006.01) A61K 31/435 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07H 19/052 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01)
Patent
CA 2188147
This invention relates to adenosine derivatives and analogs which possess adenosine agonist activity and are useful as anti-hypertensive, cardioprotective, anti-ischemic, and antilipolytic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypertension, myocardial ischemia, ameliorating ischemic injury and myocardial infarct size consequent to myocardial ischemia, and treating hyperlipidemia and hypercholesterolemia, and to methods and intermediates used in the preparation of such compounds.
La présente invention concerne des dérivés de l'adénosine et analogues qui présentent une activité antagoniste de l'adénosine. Ces composés interviennent dans des compositions pharmaceutiques comme principes anti-hypertenseurs, cardioprotecteurs, anti-ischémiants, et antilipolytiques. Ils permettent de traiter l'hypertension, l'ischémie du myocarde, une évolution favorable des lésions ischémiques et de l'infarctus du myocarde consécutifs à une ischémie du myocarde, et de traiter l'hyperlipidémie et l'hypercholestérolémie. L'invention concerne également des procédés et des intermédiaires utilisés dans la préparation de tels composés.
Fink Cynthia A.
Myers Michael R.
Spada Alfred P.
Aventis Pharmaceuticals Inc.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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