C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/34 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 31/70 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07H 19/16 (2006.01) C07H 19/23 (2006.01)
Patent
CA 2259538
This invention relates to adenosine derivatives and analogues of formula I below: (see formula I) which possess biological activity and are useful as anti-hypertensive, cardioprotective, anti- ischemic, and antilipolytic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypertension, myocardial ischemia, ameliorating ischemic injury and myocardial infarct size consequent to myocardial ischemia, and treating hyperlipidemia and hypercholesterolemia, and to methods and intermediates used in the preparation of such compounds.
La présente invention concerne des dérivés de l'adénosine et analogues qui présentent une activité biologique. Ces composés interviennent dans des compositions pharmaceutiques comme principes anti-hypertenseurs, cardioprotecteurs, anti-ischémiques et antilipolytiques. Ils permettent de traiter l'hypertension, l'ischémie myocardique, l'hyperlipidémie ainsi que l'hypercholestérolémie, et d'assurer une évolution favorable des lésions ischémiques et de la taille de l'infarctus du myocarde consécutifs à une ischémie myocardique. L'invention concerne également des procédés et des intermédiaires utilisés dans la préparation de tels composés.
Choi-Sledeski Yong-Mi
Ewing William R.
Maguire Martin P.
Myers Michael R.
Pauls Henry W.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Sanofi-Aventis Deutschland Gmbh
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