C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/220.2
C08B 37/16 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01)
Patent
CA 1234106
- 21 - Abstract: New compounds having antiinflammatory activity, obtained by complexation with .beta.-cyclodextrin, and pharmaceutical compositions containing them New inclusion compounds of 4-hydroxy-2-methyl- N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide- 1,1-dioxide with .alpha., .beta. or .gamma. cyclodextrins, obtained by reaction of said cyclodextrins and said 4-hy- droxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine- 3-carboxyamide-1,1-dioxide in aqueous or water/ organic solutions are described. The ratio bet- ween 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzo thiazine-1,1-dioxide and the cyclodextrins is com prised between 1:10 and 1:1; preferably, it is about 1:2.5. The compounds of the invention possess high an tiinflammatory and analgesic activities, together with a considerably reduced gastrolesive action.
474850
Chiesi Paolo
Servadio Vittorio
Chiesi Farmaceutici S.p.a.
Kirby Eades Gale Baker
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