C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/439 (2006.01) C07D 453/02 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2503786
The invention discloses compounds that are selective .alpha.7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases. The compounds have the following Formula (I): Azabicyclo-N(H)-C(=O)- W0wherein Azabicyclo is Formula (2) each R1 is independently H, alkyl, or substituted alkyl; R2 is H, alkyl, or substituted alkyl; k is 1 or 2, provided that one R2 is other than H when k is 2; R3 is H, alkyl, or an amino protecting group; W0 is Formula (3); W is CH or N; W1 is O, N(R4), N(C(O)R4), or S; W2 is O, N(R4), N(C(O)R4), or S; R is H, F, Cl, Br, I, alkyl, substituted alkyl, or alkynyl; Alkyl is both straight- and branched-chain moieties having from 1-6 carbon atoms.
L'invention concerne des composés agonistes sélectifs d'.alpha.7 nAChR et antagonistes de 5- HT¿3?. Ces composés sont utiles pour traiter un grand nombre de maladies du système nerveux central.
Acker Brad Alan
Cortes-Burgos Luz Amparo
Jacobsen Eric Jon
Piotrowski David Walter
Rogers Bruce Nelsen
Pharmacia & Upjohn Company Llc
Smart & Biggar
LandOfFree
Compounds having both alpha7 nicotinic agonist activity and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds having both alpha7 nicotinic agonist activity and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having both alpha7 nicotinic agonist activity and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1559807