C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 211/18 (2006.01) C07D 211/70 (2006.01) C07D 295/096 (2006.01) C07D 311/72 (2006.01) C07D 409/06 (2006.01) C07D 411/06 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2153979
Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed. The invention relates to a compound of the formula: A~Y~B wherein: A is an antioxidant selected from: Image wherein R is C1 to C6 alkyl, Y is (CH2)n or CH=CH(CH2)n, wherein n is a whole number of from 1 to 6; and B is selected from: Image Image wherein: n' is a whole number of from 1 to 6; Z is H, CN or OH; X is F, Cl, I, Br, OH, OR', SH, S(O)m R', CN or NO2, wherein R' is C1 to C6 alkyl and m is 0, 1 or 2; and o is 0, 1, 2 or 3, or a pharmaceutically acceptable salt thereof.
L'invention concerne des composés présentant une activité d'antagonistes du calcium et d'antioxydants utiles dans la prévention ou l'atténuation de dommages tissulaires au niveau cellulaire. Des procédés de traitement dans lesquels les propriétés desdits composés sont utilisées et des compositions pharmaceutiques correspondantes sont également décrits.
Barnes George
Collier Robert J. Jr.
Hellberg Mark
Alcon Laboratories Inc.
Smart & Biggar
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