Compounds having crth2 antagonist activity

Details Compounds having crth2 antagonist activity Compounds having crth2 antagonist activity

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2712017

Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, - CONR2R3, -NO2, -OR2, -SR2, -O(CH2)p OR2, and -O(CH2)p O(CH2)q OR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

L'invention porte sur des composés représentés par la formule générale (I), dans laquelle W représente chloro ou fluoro ; R1 représente phényle éventuellement substitué par un ou plusieurs substituants choisis parmi halo, -CN, alkyle en C1-C6, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, - CONR2R3, -NO2, -OR2, -SR2, -O(CH2)POR2, et -O(CH2)pO(CH2)qOR2, où les R2 représentent chacun indépendamment hydrogène, alkyle en C1-C6, cycloalkyle en C3-C8, aryle ou hétéroaryle ; les R3 représentent chacun indépendamment alkyle en C1-C6, cycloalkyle en C3-C8, aryle ou hétéroaryle ; p et q représentent chacun indépendamment un entier de 1 à 3 ; et sur leurs sels, hydrates, solvates, complexes ou promédicaments pharmaceutiquement acceptables, qui sont utiles dans des compositions administrables par voie orale pour le traitement de maladies allergiques, telles que l'asthme, la rhinite allergique et la dermatite atopique.

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