C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2257962
A series of 1-(4-indolyloxy)-3-(4-hydroxy-4-naphthyl-piperidin-1-yl)propanes are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor, yet lack mutagenic potential as measured by assays of chromosomal aberration. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
La présente invention concerne une série de 1-(4-indolyloxy)-3-(4-hydroxy-4-naphthyl-piperidin-1-yl) propanes qui constituent des médicaments efficaces pour le traitement d'états liés ou influencés par la réabsorption de la sérotonine et par le récepteur 1¿A? de la sérotonine, tout en étant dénués de pouvoir mutagène tel que mesuré dans les analyses d'aberrations chromosomiques. Ces composés sont particulièrement utiles pour soulager les symptômes du sevrage à la nicotine et au tabac et pour le traitement de la dépression et d'autres états dans lesquels des inhibiteurs de réabsorption de la sérotonine sont utilisés.
Koch Daniel James
Rocco Vincent Patrick
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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