Compounds having improved fluorescence in fluorescence...

C - Chemistry – Metallurgy – 07 – D

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C07D 493/10 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2108919

ABSTRACT Compounds of the formula Image I wherein F is a fluorescing compound; Y is -NH- or a single covalent bond; Z is a straight or branched alkylene chain of 2 to 10 carbon atoms which is substituted by at least one hydrophilic group; Q is oxygen or sulfur; and X is a ligand-analog, the ligand- analog capable of being recognized by an antibody specific to the corresponding ligand. These compounds have improved properties in fluorescence polarization immunoassays by possessing either a better intensity and/or a larger span.

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