Compounds having inhibitive activity of phosphatidylinositol...

A - Human Necessities – 61 – K

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A61K 31/4745 (2006.01) A61K 31/437 (2006.01) A61K 35/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2528938

Compounds inhibiting phosphatidylinositol 3-kinase (PI 3-K) activities and methods of preparing and using thereof in treating diseases are disclosed. Compounds inhibiting PI 3-K activity and methods of using PI 3-K inhibitory compounds to inhibit cancer cell grwoth or to treat disorders of immunity and inflammation, in which PI 3-K plays a role in leukocyte function are also provided.

L'invention concerne des composés inhibant les activités de la phosphatidylinositol 3-kinase (PI 3-K) et son utilisation dans le traitement de maladies. L'invention concerne également des composés inhibant l'activité de la PI 3-K et des procédés d'utilisation de composés d'inhibition de la PI 3-K permettant d'inhiber la croissance des cellules cancéreuses ou de traiter les troubles immunitaires ou inflammatoires, dans lesquels la PI 3-K joue un rôle dans la fonction des leucocytes.

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