C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 249/00 (2006.01) C07C 211/00 (2006.01) C07C 229/00 (2006.01) C07C 251/24 (2006.01) C07C 323/58 (2006.01) C07D 209/20 (2006.01) C07F 9/02 (2006.01)
Patent
CA 2389229
There is disclosed a genus of optionally substituted Schiff base condensation products (and the carba analogs thereof) comprising an amino acid component and a benzaldehyde component, that have MIF (macrophage migration inhibitory factor) antagonist activity. The compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases, asthma, arthritis, EAE, ARDS and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization.
L'invention concerne un genre de produits de condensation éventuellement substitués en base de Schiff (et les analogues de carba associés) comprenant un composant d'acide aminé et un composant de benzaldéhyde, présentant une activité antagoniste du MIF (facteur d'inhibition de la migration des macrophages). Les composés sont utiles pour traiter une variété de maladies donnant lieu à une activité inflammatoire ou à des réponses d'une cytokine pro-inflammatoire, telles que des maladies auto-immunes, l'asthme, l'arthrite, l'EAE, la SDRA et diverses formes de sepsie et de chocs infectieux, ainsi que d'autres affections caractérisées par des réponses du MIF sous-jacentes comprenant, par exemple, la croissance tumorale et la néovascularisation.
Al-Abed Yousef
Bucala Richard
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Picower Institute For Medical Research
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