C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/179, 260/228
C07C 307/02 (2006.01) A61K 31/255 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01) A61K 31/70 (2006.01) C07D 207/27 (2006.01) C07D 209/08 (2006.01) C07D 211/22 (2006.01) C07D 213/65 (2006.01) C07D 215/26 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 277/14 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 285/10 (2006.01) C07D 311/16 (2006.01) C07D 319/20 (2006.01) C07D 521/00 (2006.01) C07H 11/00 (2006.01)
Patent
CA 2018700
AHR-484 ABSTRACT OF THE INVENTION Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p-A-[-OS(0)2NR1R2]z wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of -OS(0)2NR1R2 groups and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
Lo Young Sek
Nolan Joseph Clarence
Walsh David Allan
Welstead William John Jr.
Ahp Subsidiary (9) Corporation
Ridout & Maybee Llp
LandOfFree
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