C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/44 (2006.01) A61K 31/426 (2006.01) A61K 31/429 (2006.01) A61P 7/04 (2006.01) A61P 43/00 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2535511
The present invention provides a compound represented by the general formula (I): (see formula I) wherein R1 is a hydrogen atom, a halogen atom, or the like; R2, R3, and R4 are each independently a hydrogen atom, a halogen atom, C1-C15 alkyl optionally substituted with one or more C1-C12 alkyloxy or the like, or the like; R5 is a hydrogen atom or the like; R6 and R7 are a hydrogen atom or the like; R8 is C1-C3 alkyl or the like; R9 is a hydrogen atom or the like), and a prodrug, pharmaceutically-acceptable salt, or solvate thereof. Also provided are uses of the compound, prodrug, salt, and solvate for modifying platelet production.
L'invention porte sur des composés de formule générale (I), leurs prodrogues et leurs sels pharmacocompatibles, et leurs solvates. Dans ladite formule: R<1> est hydrogène, halogéno, ou analogue; R<2>, R<3> et R<4> sont chacun indépendamment hydrogène, halogéno, C1-15 alkyle facultativement substitué par C1-12 alkyloxy ou analogue en une ou plusieurs positions, ou analogue; R<5> est hydrogène ou analogue; R<6> et R<7> sont chacun halogéno ou analogue; R<8> est C1-3 alkyle ou analogue; et R<9> est hydrogène ou analogue.
Takayama Masami
Yoshida Yutaka
Mccarthy Tetrault Llp
Shionogi And Co. Ltd.
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