Compounds inhibiting the aggregation of superoxide dismutase-1

Details Compounds inhibiting the aggregation of superoxide dismutase-1 Compounds inhibiting the aggregation of superoxide dismutase-1

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) A61K 31/00 (2006.01) C07D 241/18 (2006.01) C07D 253/075 (2006.01) C12N 9/96 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2598451

The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.

L'invention concerne des méthodes permettant d'inhiber la vitesse à laquelle la superoxyde dismutase-1 (SOD) s'agrège à l'aide de composés qui stabilisent des dimères SOD. On utilise ces méthodes pour l'étude et la thérapie de la sclérose latérale amyotrophique. L'invention concerne également des dosages qui peuvent être utilisés pour identifier des composés qui stabilisent des dimères et des molécules SOD modifiés pour être utilisés dans lesdits dosages.

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