A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01)
Patent
CA 2503962
Methods, compositions and devices for inhibiting neoproliferative changes in blood vessel walls or other anatomical structures. One or more compounds of Formula (I) or (I-A) set forth herein are administered systemically and/or locally to human or veterinary patients to deter or prevent unwanted proliferative changes in blood vessels or other anatomical structures. The invention may be used to deter or prevent stenosis or restenosis of arteries following angioplasty and/or stent placement. In one embodiment, there is provided an implantable stent or stent graft from which one or more compounds of the present invention will elute or otherwise be delivered into an affected blood vessel wall.
L'invention porte sur des procédés, compositions et dispositifs inhibant les modifications néoprolifératives non souhaitées de la paroi des vaisseaux sanguins ou d'autres structures anatomiques. A cet effet, on administre un ou plusieurs composés de formule (I) ou (Ia) systémiquement ou localement à des patients ou des animaux. L'invention peut servir à empêcher ou prévenir la sténose ou la resténose d'artères, suite à une angioplastie et/ou à la mise en place d'un stent. L'une des exécution a trait à un stent ou à un stent greffe implantable d'où diffuseront ou seront libérés d'autre façon un ou plusieurs des composés de l'invention dans la paroi du vaisseau sanguin lésé.
Chandy K. George
Hoyer Joachim
Koehler Ralf
Wulff Heike
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
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