Compounds named the adenophostins, their preparation and...

Details Compounds named the adenophostins, their preparation and... Compounds named the adenophostins, their preparation and...

C - Chemistry, Metallurgy

12

N

C12N 1/14 (2006.01) A61K 31/70 (2006.01) C07H 19/20 (2006.01) C12P 19/32 (2006.01)

Patent

CA 2076060

Compounds of formula (I): Image (wherein R represents a hydrogen atom or an acetyl group); which eve have named "the adenophostins", and salts and esters thereof, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphosphate (InsP3) receptors which exist in the endoplasmic reticulum, and can therefore be used fox the treatment or prophylaxis of cerebral disorders. They can be prepared by cultivation of a microorganism of the genus Penicillium, e.g. Penicillium brevicompactum SANK 11991 (FERM BP-3499) or Penicillium brevicompactum SANK 12177 (FERM BP-3500).

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