Compounds, named the "leustroducins", their preparation and...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/14 (2006.01) A61K 31/665 (2006.01) C07F 9/655 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2064126

ABSTRACT OF THE DISCLOSURE New compounds, which we have named the "Leustroducsins" have the formula (I): Image (I) in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis. such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

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