Compounds of heteroaryl substituted imidazole, their...

Details Compounds of heteroaryl substituted imidazole, their... Compounds of heteroaryl substituted imidazole, their...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2314980

Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).

L'invention concerne des composés d'imidazole 1,4,5-substitués, un des substituants pouvant être une pyrimidine, une pyridazine ou une 1,2,4-triazine substituée. Ces composés et leurs compositions pharmaceutiques s'utilisent pour le traitement d'affections liées à la cytokine par inhibition de la production d'IL-1 (interleukine-1), d'IL-8 (interleukine-8) et de TNF (facteur de nécrose des tumeurs).

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