C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/67
C07J 5/00 (2006.01) C07J 31/00 (2006.01) C07J 33/00 (2006.01) C07J 41/00 (2006.01)
Patent
CA 1114367
Compounds of the pregnane series with an oxygen function in the 19-position, processes for their manufacture and pharmaceutical preparations containing these compounds Abstract of the Disclosure 19-Oxygenated steroid compounds of the pregnane series of the formula I Image (I) in which R1 represents a hydrogen atom, and R2 represents an .alpha.-oriented lower alkanoylthio group, or R1 and R2 together represent a carbon-carbon bond or an .alpha.- or .beta.-oriented methylene radical, R3 represents a free hydroxymethyl group or a hydroxy- methyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a formyl group, a carboxyl group or a lower alkoxycarbonyl group, and R4 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, and corresponding 1,2-dehydro derivatives have valuable aldosterone-antagonising properties with a minimum effect on sexual functions. As the compounds reduce the excessive sodium retention and potassium excretion induced by aldosterone, they are especially useful as the active ingredient in pharmaceutical preparations for alleviating diseases involving hyperaldosteronismus in man and other warm-blooded animals.
304525
Fetherstonhaugh & Co.
Novartis Ag
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