Compounds of unstable dipeptidyl peptidase iv inhibitors

Details Compounds of unstable dipeptidyl peptidase iv inhibitors Compounds of unstable dipeptidyl peptidase iv inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/083 (2006.01) A61K 38/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335978

The invention relates to compounds of unstable inhibitors of dipeptidyl peptidase IV (DP IV) which comprise general formula A-B-C, whereby A represents an amino acid, B represents the chemical bond between A and C or an amino acid, and C represents an unstable inhibitor of DP IV. Such compounds are used for treating altered glucose tolerance, glucosuria, hyperlipidemia, metabolic acidoses, diabetes mellitus, diabetic neuropathy, nephropathy, and secondary diseases in mammals caused by diabetes mellitus.

L'invention concerne des composés d'inhibiteurs instables de la dipeptidylpeptidase IV (DP IV), qui présentent la formule générale A-B-C, dans laquelle A est un aminoacide, B est la liaison chimique entre A et C ou un aminoacide, et C est un inhibiteur instable de la DP IV. Ces composés s'utilisent pour traiter la tolérance glucidique altérée, la glucosurie, l'hyperlipidémie, les acidoses métaboliques, le diabète sucré, la neuropathie et la néphropathie diabétiques, ainsi que les maladies provoquées par le diabète sucré chez les mammifères.

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