C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/16 (2006.01) A61K 31/395 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2055225
NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Abstract The invention relates to novel compounds of the general formula (I), Image (I) wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R1 stands for hydrogen or a straight or branched chain C1-6alkyl group; R2 represents hydrogen or a straight or branched chain C1-6alkyl group; R3 means hydrogen; a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s); or a C4-7cycloalkyl group; R4 stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s); or a C4-7cycloalkyl group; or R3 and R4 together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula Image optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R5 group may be substituted for a ring carbon atom, where R5 means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R6 stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeu- tically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.
Bencze Zsolt
Debreczeni Lorand
Gaal Jozsef
Hermecz Istvan
Kapui Zoltan
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt
Fetherstonhaugh & Co.
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