Compounds resistant to metabolic deactivation and methods of...

Details Compounds resistant to metabolic deactivation and methods of... Compounds resistant to metabolic deactivation and methods of...

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/70 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2508479

Therapeutic compounds having increased resistance to deamination and inactivation by metabolic enzymes are provided. The compounds include nucleotide analogs and nucleotide analogs, derivatized with aminal and/or thioaminal groups to prevent deamination of free amine. The compounds can be used in a variety of treatments, including treatment of neoplastic disorders, infections from fungal or fungal like organisms, and infections from parasites.

La présente invention concerne des composés thérapeutiques qui présentent une résistance augmentée à la déamination et à l'inactivation par les enzymes métaboliques. Les composés de l'invention comprennent des analogues de nucléotides et des analogues de nucléosides, qui ont été substitués par des groupes amino et/ou thioamino afin d'empêcher la déamination de l'amine libre. Les composés précités peuvent être utilisés dans une variété de traitements, y compris le traitement de troubles néoplastiques, d'infections causées par des organismes fongiques ou de type fongique et d'infections parasitaires.

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