C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 31/70 (2006.01) A61K 39/42 (2006.01) C07H 21/04 (2006.01) C07K 14/045 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2329868
Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.
L'invention porte sur de nouveaux polypeptides ayant une activité anti-apoptique, et sur des procédés de criblage de ces nouveaux polypeptides, ainsi que sur des polynucléotides codant ces polypeptides. L'invention porte en outre sur des composés qui régulent ou modulent l'apoptose et/ou l'activité anti-apoptique tels que des composés ayant une activité anti-apoptique, et des composés qui induisent, rétablissent ou modulent l'apoptose et/ou inhibent, diminuent ou modulent l'activité anti-apoptique. L'invention porte sur des procédés de criblage et d'utilisation de ces composés dans les interventions thérapeutiques pour traiter des pathologies; sur des procédés de traitement des cellules eucaryotiques avec des composés qui régulent ou modulent l'apoptose et/ou l'activité anti-apoptique; sur des procédés visant à améliorer la stabilité, la prolifération et/ou la productivité des cellules eucaryotiques; et sur des compositions pharmaceutiques qui régulent ou modulent l'apoptose et/ou l'activité anti-apoptique.
Bartle Laura
Goldmakher Viktor S.
Skaletskaya Anna
Apoptosis Technology Inc.
Mcmillan Llp
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