C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 47/48 (2006.01) C07C 323/41 (2006.01) C07C 323/59 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2415478
A soluble derivative of a soluble polypeptide, which comprises two or more heterologous membrane binding elements with low membrane affinity covalently associated with the polypeptide, the elements being soluble in aqueous solution, and the elements being capable of interacting, independently and with thermodynamic additivity, with components of cellular or artificial membranes exposed to extracellular fluids, characterised in that the membrane binding elements target lipid raft components of the membrane and bind to the lipid rafts to localize the polypeptide at the lipid rafts.
L'invention concerne un dérivé soluble d'un polypeptide soluble qui comprend au moins deux éléments de liaison hétérologues membranaires comportant une basse affinité de membrane associés en liaison covalente avec le polypeptide, ces éléments étant solubles en solution aqueuse et pouvant agir en interaction, de manière indépendante et avec une additivité thermodynamique, avec des composants de membranes cellulaires ou artificielles exposées aux liquides extracellulaires, caractérisés par le fait que les éléments de liaison membranaires ciblent les composants de type radeau lipidique et se fixent à ces radeaux lipidiques pour situer le polypeptide sur les radeaux lipidiques.
Ridley Simon Hugh
Rowling Pamela Jane Elizabeth
Smith Geoffrey Paul
Adprotech Limited
Sim & Mcburney
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