C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/773 (2006.01) A61K 31/235 (2006.01) A61P 35/00 (2006.01) C07C 69/76 (2006.01) C07C 69/78 (2006.01) C07C 327/26 (2006.01) C07C 327/36 (2006.01) C07D 213/65 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2487388
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat Proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.
L'invention concerne des compositions et des procédés destinés à supprimer le point de contrôle G2 du cycle cellulaire, notamment le point de contrôle induit par l'ADN endommagé, dans des cellules mammaliennes, notamment des cellules humaines. Plus particulièrement, l'invention concerne des compositions et des procédés destinés à sensibiliser des cellules à des agents endommageant l'ADN par inhibition du point de contrôle G2 du cycle cellulaire. Les composés de l'invention sont utilisés en vue de traiter des troubles prolifératifs tels que le cancer. Cette invention concerne enfin des compositions et des procédés destinés à sensibiliser, de façon sélective, des cellules cancéreuses abîmées du point de contrôle G1 aux traitements et aux agents endommageant l'ADN.
Kawabe Takumi
Kobayashi Hidetaka
Canbas Co. Ltd.
Mbm Intellectual Property Law Llp
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