A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2430918
The present invention relates to compounds that specifically block the binding between a member of the HuR family of proteins and a mRNA encoding a member of the CD83 family of proteins and that reduce expression of a member of the CD83 family of proteins in a cell as well as pharmaceutical compositions comprising such compounds and methods for screening and/or identifying compounds that block the binding between a member of the HuR family of proteins and a mRNA encoding a member of the CD83 family of proteins.
La présente invention concerne des composés qui bloquent de façon spécifique la liaison entre d'une part un membre de la famille de protéines HuR, et d'autre part un ARN médiateur codant un membre de la famille de protéines CD83. Ces composés réduisent également l'expression d'un membre de la famille de protéines CD83 dans une cellule. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des procédés permettant une recherche systématique et/ou l'identification de composés qui bloquent la liaison entre d'une part un membre de la famille de protéines HuR, et d'autre part un ARN médiateur codant un membre de la famille de protéines CD83.
Hauber Joachim
Prechtel Alexander Thorsten
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Viaxxel Biotech Gmbh
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