Compounds that enhance atoh1 expression

Details Compounds that enhance atoh1 expression Compounds that enhance atoh1 expression

A - Human Necessities

61

K

A61K 31/4184 (2006.01) C12N 5/071 (2010.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) A61K 31/423 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/437 (2006.01) A61K 31/517 (2006.01) A61K 35/12 (2006.01) A61P 27/16 (2006.01)

Patent

CA 2714370

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Cette invention concerne dune manière générale des composés, des compositions pharmaceutiques et leurs procédés dutilisation, notamment des procédés qui aboutissent à lexpression accrue dun gène Atoh1 (Hath1 par exemple) dans une cellule biologique. Linvention concerne plus spécifiquement le traitement de maladies et/ou daffections susceptibles de tirer avantage dune expression accrue du gène Atoh1, par exemple laltération de laudition, un trouble de léquilibre associé avec une perte des cellules auditives internes, ou une affection associée avec une prolifération cellulaire anormale.

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