C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/94 (2006.01) A61K 31/335 (2006.01) A61K 31/42 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2097826
2097826 9210096 PCTABS00013 The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the pharmaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activities, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
Bradbury Barton J.
Ip Stephen H.
Kaufman Teodoro S.
Lee Chew
Marsh Henry C. Jr.
Osler Hoskin & Harcourt Llp
T. Cell Sciences Inc.
University Of Mississippi (the)
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