Compounds that inhibit interaction between...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/04 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2260742

This invention provides for a composition capable of inhibiting specific binding between a signal-transducing protein and a cytoplasmic protein. This invention also provides a method of identifying a compound capable of inhibiting specific binding between a signal-transducing protein and a cytoplasmic protein. This invention also provides a method of inhibiting the proliferation of cancer cells. This invention also provides a method of treating cancer with a composition in an amount effective to result in an amount in apoptosis of the cells. This invention also provides a method of inhibiting the proliferation of virally infected cells. This invention also provides for a method of treating a virally-infected subject with a composition in an amount effective to result in apoptosis of the cells. This invention also provides for pharmaceutical compositions.

La présente invention concerne un composé capable d'inhiber des liaisons spécifiques entre une protéine transductrice de signaux et une protéine cytoplasmique. L'invention concerne également un procédé d'identification d'un composé capable d'inhiber des liaisons spécifiques entre une protéine transductrice de signaux et une protéine cytoplasmique. L'invention concerne en outre un procédé d'inhibition de la prolifération de cellules cancéreuses, ainsi qu'une thérapie anticancéreuse utilisant une composition en quantité suffisante pour aboutir à l'apoptose des cellules. L'invention concerne aussi un procédé d'inhibition de la prolifération de cellules infectées par voie virale, ainsi qu'une thérapie, adaptée au traitement de sujets infectés par voie virale, et utilisant une composition en quantité suffisante pour aboutir à l'apoptose des cellules. L'invention concerne enfin de telles compositions pharmaceutiques.

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