C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/48 (2006.01) A61K 31/36 (2006.01)
Patent
CA 2328234
A method for the inhibition of the binding of .alpha.4.beta.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or preventions of diseases states in which .alpha.4.beta.1 is involved.
L'invention concerne une méthode permettant d'inhiber la fixation d'une intégrine alpha 4 beta 1 à ses récepteurs, par exemple la VCAM-1 (molécule-1 d'adhésion cellulaire vasculaire) et la fibronectine. L'invention concerne également des composés destinés à inhiber cette fixation, des compositions pharmaceutiques actives renfermant ces composés, et l'utilisation de ces composés dans le but susmentionné ou dans des formulations visant à prévenir ou à traiter des troubles liés à la alpha 4 beta 1.
Biediger Ronald J.
Grabbe Vanessa O.
Kassir Jamal M.
Keller Karin M.
Kogan Timothy P.
Encysive Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Texas Biotechnology Corporation
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