C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/715 (2006.01) A61K 38/20 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2256109
The invention relates to compounds, such as proteins, peptides and organic compounds, capable of blocking or inhibiting the binding interaction of Raf-1 or 14-3-3 proteins to the .beta. chain of IL-2, and pharmaceutical compositions containing such compounds. In vitro assays for isolating, identifying and characterizing such compound capable of inhibiting interaction of Raf-1 or 14-3-3 proteins to IL-2.beta. are also provided.
L'invention concerne des composés tels que des protéines, des peptides et des composés organiques, capables de bloquer ou d'inhiber l'interaction de liaison des protéines Raf-1 ou 14-3-3 à la chaîne .beta. d'IL-2, ainsi que compositions pharmaceutiques contenant lesdits composés. Elle porte également sur des analyses in vitro pour isoler, identifier et caractériser ledit composé capable d'inhiber l'interaction des protéines Raf-1 ou de 14-3-3 avec IL-2.beta..
Maslinski Wlodzimierz
Strom Terry
Applied Research Systems Ars Holding N.v.
Gowling Lafleur Henderson Llp
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