C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0735 (2010.01) C12N 5/07 (2010.01) C07D 487/04 (2006.01)
Patent
CA 2610598
The present invention relates to methods and compositions for culturing embryonic stem (ES) cells. The methods relate to growing the ES cells in the presence of small molecules of formula (I) that maintain the pluripotency/self- renewal of the cells without feeder cells and LIF in serum-free conditions. These methods in part facilitate much more consistency in embryonic stem cell production, providing, for example, new avenues in the practical applications of embryonic stem cells in regenerative medicine.
La présente invention concerne des procédés et des compositions pour la culture de cellules souches embryonnaires (ES). Les procédés concernent la croissance de cellules ES en présence de petites molécules de la formule I qui maintiennent le caractère pluripotent/d~auto-renouvellement des cellules sans cellules nourricières ni LIF dans des conditions sans sérum. Ces procédés contribuent en partie à une consistance bien supérieure dans la production de cellules souches embryonnaires, procurant, par exemple, de nouvelles avenues dans des applications pratiques de cellules souches embryonnaires en médecine régénératrice.
Chen Shuibing
Ding Sheng
Schultz Peter G.
Yan Feng
Fetherstonhaugh & Co.
Irm Llc
The Scripps Research Institute
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