C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/12 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2653327
The present invention relates to compositions and methods related to inhibitors of Hsp90, including substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in heed thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. The invention further provides methods for designing and identifying inhibitors of Hsp90.
Compositions et méthodes concernant des inhibiteurs de Hsp90, dont des composés triazole substitués et des compositions renfermant ces composés. L'invention concerne également des méthodes d'inhibition de l'activité de Hsp90 chez un sujet qui en a besoin et des méthodes de prévention et de traitement de troubles hyperprolifératifs tels que le cancer chez un tel sujet, consistant à administrer à ce dernier un composé triazole substitué de l'invention, ou bine une composition comprenant un tel composé. Sont également décrites des méthodes de conception et d'identification d'inhibiteurs de Hsp90.
Gowling Lafleur Henderson Llp
Synta Pharmaceuticals Corp.
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