A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4245 (2006.01) A61K 31/352 (2006.01) A61K 31/40 (2006.01) A61K 31/4422 (2006.01) A61K 31/7048 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61P 31/14 (2006.01) A61P 31/16 (2006.01)
Patent
CA 2717119
The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative-sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative- sense, single-stranded RNA viruses, in particular, influenza virus.
La présente invention porte sur des composés qui modulent la réplication de virus à ARN simple brin, sens négatif, tels que le virus de la grippe, et sur l'utilisation de tels composés. L'invention porte sur des procédés pour augmenter le titre de virus à ARN simple brin, sens négatif, tels que le virus de la grippe, dans des substrats pour la propagation du virus (par exemple, culture tissulaire). L'invention porte également sur l'utilisation de composés qui diminuent la réplication virale en tant qu'agents antiviraux. L'invention porte en outre sur des procédés pour identifier des composés qui modulent la réplication de virus à ARN simple brin, sens négatif, en particulier le virus de la grippe.
Garcia-Sastre Adolfo
Hoffmann Hans-Heinrich
Palese Peter
Shaw Megan L.
Mount Sinai School Of Medicine Of New York University
Osler Hoskin & Harcourt Llp
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