Compounds that modulate neuronal growth and their uses

Details Compounds that modulate neuronal growth and their uses Compounds that modulate neuronal growth and their uses

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/00 (2006.01) A61K 38/12 (2006.01) A61P 25/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/50 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2535279

Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurite outgrowth and synaptic plasticity). Cyclic peptides and peptidomimetics are also provided that block or reduce the effect of other factors that inhibit growth and/or repair of the central nervous system. Pharmaceutical compositions and other formulations comprising these compounds are provided. In addition, the invention provides methods for using the cyclic peptides and peptidomimetics to modulate Trk mediated activities, including processes such as neuronal growth, survival and recover, axonal growth, neurite outgrowth, and synaptic plasticity. Further, the invention provides methods for promoting central nervous system (CNS) neuron growth by administering a p75 receptor binding agent.

L'invention concerne des peptides cycliques et de peptidomimétiques qui se fixent à et/ou modulent les activités associées aux récepteurs Trk, notamment des processus associés à la croissance et à la réparation du système nerveux central (par exemple, croissance et survie neuronale, croissance axonale, développement de neurites et plasticité synaptique). L'invention concerne également des peptides cycliques et des peptidomimétiques qui bloquent ou réduisent l'effet d'autres facteurs qui inhibent la croissance et/ou la réparation du système nerveux central. L'invention concerne des composition pharmaceutiques et d'autres préparations comprenant lesdits composés. De plus, l'invention concerne des méthodes d'utilisation desdits peptides cycliques et peptidomimétiques pour moduler les activités induites par les Trk, notamment des processus tels que la croissance, la survie et la récupération neuronale, la croissance axonale, le développement de neurites et la plasticité synaptique. En outre, l'invention concerne des méthodes permettant de favoriser la croissance neuronale au niveau du système nerveux central (SNC) par administration d'un agent de liaison du récepteur p75.

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