C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/20 (2006.01) A61K 31/19 (2006.01) A61K 31/4418 (2006.01) A61K 31/443 (2006.01) A61P 3/04 (2006.01) C07D 213/32 (2006.01) C07D 405/12 (2006.01) C07C 59/70 (2006.01)
Patent
CA 2481246
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of suppressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.
L'invention concerne des composés altérant l'activité PPAR. L'invention concerne également des sels pharmaceutiquement acceptables des composés, des compositions pharmaceutiquement acceptables contenant les composés ou leurs sels et leurs procédés d'utilisation comme agents thérapeutiques dans le traitement ou la prévention d'hyperlipidémie, d'hypercholestérémie, de l'obésité, des troubles de l'alimentation, d'hyperglycémie, d'athérosclérose, d'hypertriglycéridémie, d'hyperinsulinémie et de diabète chez un mammifère ainsi que des procédés de suppression de l'appétit et de modulation des niveaux de leptine chez un mammifère. La présente invention concerne en outre des procédés de préparation desdits composés.
Auerbach Bruce Jeffrey
Bratton Larry Don
Filzen Gary Frederick
Geyer Andrew George
Trivedi Bharat Kalidas
Smart & Biggar
Warner-Lambert Company Llc
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