Compounds that modulate the activity of ptp-1b and tc-ptp

Details Compounds that modulate the activity of ptp-1b and tc-ptp Compounds that modulate the activity of ptp-1b and tc-ptp

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 31/343 (2006.01) A61K 31/404 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61K 31/5377 (2006.01) A61K 31/635 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 307/78 (2006.01) C07D 307/80 (2006.01) C07D 307/82 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2477119

The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B (~PTP-1B~). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase (~TC-PTP~). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.

La présente invention concerne une nouvelle méthode améliorée destinée à traiter le diabète et/ou les complications qui lui sont associées par modulation de l'activité de la protéine tyrosine phosphatase 1B (PTP-1B). Les composés de l'invention modulent l'activité de PTP-1B par liaison à un nouveau site de liaison désigné sous le nom d'exosite de PTP-1B, lequel est distal par rapport au site actif de PTP-1B. La présente invention concerne également une nouvelle méthode améliorée destinée à traiter des troubles du système immunitaire par modulation de l'activité de la protéine tyrosine phosphatase des lymphocytes T (TC-PTP). Les composés de l'invention modulent l'activité de TC-PTP par liaison à un nouveau site de liaison désigné sous le nom d'exosite de TC-PTP, lequel est distal par rapport au site actif de PTP-1B.

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