Compounds useful as a3 adenosine receptor agonists

Details Compounds useful as a3 adenosine receptor agonists Compounds useful as a3 adenosine receptor agonists

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/4745 (2006.01) A61K 31/52 (2006.01) A61K 31/7076 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01)

Patent

CA 2474337

Adenosine analogue-type A3 receptor agonists having an N6 nitrogen substituted by a group which is usually -CH2-CYCLE, where CYCLE is a specified heteroaromatic group, particularly a pyrridyl or a bicyclic group, for example benzoxazole. Preferred CYCLE moieties are substituted in specified positions by, in particular, halo or methyl and, at another position, a dialkylamine.

L'invention concerne des agonistes des récepteurs A3 des analogues de l'adénosine comprenant un azote N6 substitué par un groupe qui est habituellement -CH¿2?-CYCLE, où CYCLE représente un groupe hétéroaromatique spécifique, notamment un groupe pyrridyle ou bicyclique, par exemple le benzoxazole. Des fractions de CYCLE préférées sont substituées dans des positions spécifiques, notamment par halo ou méthyle et, dans une autre position, une dialkylamine.

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