C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/54 (2006.01) C07D 333/38 (2006.01) C07D 417/06 (2006.01) C07D 498/04 (2006.01) C07D 517/04 (2006.01)
Patent
CA 2195417
The invention relates to compounds, such as compound (1) in equilibrium with its 4-hydroxy tautomer, and its pharmaceutically acceptable salts. Such compounds are useful as inhibitors of glycinamide ribonucleotide formyl transferase (GARFT) or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds.
L'invention se rapporte à des composés tels que le composé (1) en équilibre avec son 4-hydroxy tautomère, et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles comme inhibiteurs de la glycinamide ribonucléotide formyle transférase (GARFT) ou comme agents antiprolifératifs. L'invention se rapporte également à des compositions pharmaceutiques et à des procédés mettant en oeuvre ces composés utiles comme inhibiteurs de GARFT ou comme agents antiprolifératifs. L'invention se rapporte également à des composés utiles comme intermédiaires dans la préparation de ces composés.
Palmer Cynthia L.
Romines William H.
Varney Michael D.
Agouron Pharmaceuticals Inc.
Sim & Mcburney
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